Calcitonin gene-related peptide inhibits nonadrenergic noncholinergic contraction of guinea pig distal colon.
نویسنده
چکیده
In the guinea pig distal colon, calcitonin gene-related peptide (CGRP, 0.1-30 nM) produced a concentration-dependent inhibition in electrically-evoked nonadrenergic noncholinergic (NANC) contractions and exogenous substance P-induced contractions. Both the inhibitory actions of CGRP were insensitive to human CGRP(8-37) (1-3 microM), a CGRP1 receptor antagonist. These results indicate that in the distal colon, CGRP inhibits electrically-evoked NANC contraction through a postjunctional mechanism, in contrast to our previously described results that CGRP enhances the NANC contraction of guinea pig proximal colon via a prejunctional mechanism.
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ورودعنوان ژورنال:
- Japanese journal of pharmacology
دوره 73 3 شماره
صفحات -
تاریخ انتشار 1997